Current PhD Students

Publications of J. Chai

Journal Article (35)

2024
Journal Article
Shen, Q.; Hasegawa, K.; Oelerich, N.; Prakken, A.; Tersch, L. W.; Wang, J.; Reichhardt, F.; Tersch, A.; Choo, J. C.; Timmers, T. et al.; Hofmann, K.; Parker, J. E.; Chai, J.; Maekawa, T.: Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity. Cell Host & Microbe 32, pp. P453 - 465.e6 (2024)
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Wang, X.; Yu, D.; Yu, J.; Hu, H.; Hang, R.; Amador, Z.; Chen, Q.; Chai, J.; Chen, X.: Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity. Nature Communications 15 (1), 2261 (2024)
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2023
Journal Article
Cao, Y.; Kümmel, F.; Logemann, E.; Gebauer, J. M.; Lawson, A. W.; Yu, D.; Uthoff, M.; Keller, B.; Jirschitzka, J.; Baumann, U. et al.; Tsuda, K.; Chai, J.; Schulze-Lefert, P.: Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors. Proceedings of the National Academy of Sciences of the United States of America 120 (32), e2307604120 (2023)
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Chai, J.; Song, W.; Parker, J. E.: New Biochemical Principles for NLR Immunity in Plants. Molecular Plant-Microbe Interactions 36 (8), pp. 468 - 475 (2023)
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Foerderer, A.; Chai, J.: Die another day: phytosulfokine at the molecular trade-off between growth and defense in plants. The EMBO Journal 42 (6), e113540 (2023)
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Hu, Z.; Chai, J.: Assembly and Architecture of NLR Resistosomes and Inflammasomes. Annual Review of Biophysics 52, pp. 207 - 228 (2023)
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Huang, S.; Jia, A.; Ma, S.; Sun, Y.; Chang, X.; Han, Z.; Chai, J.: NLR signaling in plants: from resistosomes to second messengers. Trends in biochemical sciences 48 (9), pp. 776 - 787 (2023)
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Jia, A.; Huang, S.; Ma, S.; Chang, X.; Han, Z.; Chai, J.: TIR-catalyzed nucleotide signaling molecules in plant defense. Current Opinion in Plant Biology 73, 102334 (2023)
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Wang, J.; Song, W.; Chai, J.: Structure, biochemical function, and signaling mechanism of plant NLRs. Molecular Plant 16 (1), pp. 75 - 95 (2023)
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Wu, Y.; Sun, Y.; Richet, E.; Han, Z.; Chai, J.: Structural basis for negative regulation of the Escherichia coli maltose system. Nature Communications 14 (1), 4925 (2023)
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Journal Article
Xu, L.; Wang, J.; Xiao, Y.; Han, Z.; Chai, J.: Structural insight into chitin perception by chitin elicitor receptor kinase 1 of Oryza sativa. Journal of Integrative Plant Biology 65 (1), pp. 235 - 248 (2023)
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Yu, Y.; Song, W.; Zhai, N.; Zhang, S.; Wang, J.; Wang, S.; Liu, W.; Huang, C.-H.; Ma, H.; Chai, J. et al.; Chang, F.: PXL1 and SERKs act as receptor-coreceptor complexes for the CLE19 peptide to regulate pollen development. Nature Communications 14 (1), 3307 (2023)
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2022
Journal Article
Foerderer, A.; Li, E.; Lawson, A. W.; Deng, Y.-N.; Sun, Y.; Logemann, E.; Zhang, X.; Wen, J.; Han, Z.; Chang, J. et al.; Chen, Y.; Schulze-Lefert, P.; Chai, J.: A wheat resistosome defines common principles of immune receptor channels. Nature 610, pp. 532 - 539 (2022)
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Journal Article
Foerderer, A.; Yu, D.; Li, E.; Chai, J.: Resistosomes at the interface of pathogens and plants. Current Opinion in Plant Biology 67, 102212 (2022)
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Gao, H.; Song, W.; Severing, E.; Vayssières, A.; Huettel, B.; Franzen, R.; Richter, R.; Chai, J.; Coupland, G.: PIF4 enhances DNA binding by CDF2 to co-regulate target gene expression and promote Arabidopsis hypocotyl cell elongation. Nature Plants 8, pp. 1082 - 1093 (2022)
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Huang, S.; Jia, A.; Song, W.; Hessler, G.; Meng, Y.; Sun, Y.; Xu, L.; Laessle, H.; Jirschitzka, J.; Ma, S. et al.; Xiao, Y.; Yu, D.; Hou, J.; Liu, R.; Sun, H.; Liu, X.; Han, Z.; Chang, J.; Parker, J. E.; Chai, J.: Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science (2022)
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Jia, A.; Huang, S.; Song, W.; Wang, J.; Meng, Y.; Sun, Y.; Xu, L.; Laessle, H.; Jirschitzka, J.; Hou, J. et al.; Zhang, T.; Yu, W.; Hessler, G.; Li, E.; Ma, S.; Yu, D.; Gebauer, J.; Baumann, U.; Liu, X.; Han, Z.; Chang, J.; Parker, J. E.; Chai, J.: TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science (2022)
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Journal Article
Liu, L.; Song, W.; Huang, S.; Jiang, K.; Moriwaki, Y.; Wang, Y.; Men, Y.; Zhang, D.; Wen, X.; Han, Z. et al.; Chai, J.; Guo, H.: Extracellular pH sensing by plant cell-surface peptide-receptor complexes. Cell 185 (18), pp. 3341 - 3355.e13 (2022)
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Qian, P.; Song, W.; Zaizen-Iida, M.; Kume, S.; Wang, G.; Zhang, Y.; Kinoshita-Tsujimura, K.; Chai, J.; Kakimoto, T.: A Dof-CLE circuit controls phloem organization. Nature Plants 8 (7), pp. 817 - 827 (2022)
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Sun, Y.; Wang, Y.; Zhang, X.; Chen, Z.; Xia, Y.; Wang, L.; Sun, Y.; Zhang, M.; Xiao, Y.; Han, Z. et al.; Wang, Y.; Chai, J.: Plant receptor-like protein activation by a microbial glycoside hydrolase. Nature 610 (7931), pp. 335 - 342 (2022)
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Yu, D.; Song, W.; Tan, E. Y. J.; Liu, L.; Cao, Y.; Jirschitzka, J.; Li, E.; Logemann, E.; Xu, C.; Huang, S. et al.; Jia, A.; Chang, X.; Han, Z.; Wu, B.; Schulze-Lefert, P.; Chai, J.: TIR domains of plant immune receptors are 2 ',3 '-cAMP/cGMP synthetases mediating cell death. Cell 185 (13), pp. 2370 - 2386 (2022)
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2021
Journal Article
Bauer, S.; Yu, D.; Lawson, A. W.; Saur, I. M. L.; Frantzeskakis, L.; Kracher, B.; Logemann, E.; Chai, J.; Maekawa, T.; Schulze-Lefert, P.: The leucine-rich repeats in allelic barley MLA immune receptors define specificity towards sequence-unrelated powdery mildew avirulence effectors with a predicted common RNase-like fold. PLoS Pathogens 17 (2), e1009223 (2021)
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Bi, G.; Su, M.; Li, N.; Liang, Y.; Dang, S.; Xu, J.; Hu, M.; Wang, J.; Zou, M.; Deng, Y. et al.; Li, Q.; Huang, S.; Li, J.; Chai, J.; He, K.; Chen, Y. h.; Zhou, J.-M.: The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling. Cell 184 (13), pp. 3528 - 3541.e12 (2021)
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Hou, S.; Liu, D.; Huang, S.; Luo, D.; Liu, Z.; Xiang, Q.; Wang, P.; Mu, R.; Han, Z.; Chen, S. et al.; Chai, J.; Shan, L.; He, P.: The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes. Nature Communications 12 (1), 5494 (2021)
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Huang, M.; Zhang, X.; Toh, G. A.; Gong, Q.; Wang, J.; Han, Z.; Wu, B.; Zhong, F.; Chai, J.: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9. Nature 592 (7856), pp. 773 - 777 (2021)
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Zhang, L.; DeGennaro, D.; Lin, G.; Chai, J.; Shpak, E. D.: ERECTA family signaling constrains CLAVATA3 and WUSCHEL to the center of the shoot apical meristem. Development 148 (5), dev189753 (2021)
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2020
Journal Article
Ma, S.; Lapin, D.; Liu, L.; Sun, Y.; Song, W.; Zhang, X.; Logemann, E.; Yu, D.; Wang, J.; Jirschitzka, J. et al.; Han, Z.; Schulze-Lefert, P.; Parker, J. E.; Chai, J.: Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science Magazine 370 (6521), eabe3069 (2020)
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Journal Article
Mahdi, L. K.; Huang, M.; Zhang, X.; Nakano, R. T.; Saur, I. M. L.; Jacob, F.; Schulze-Lefert, P.; Chai, J.; Maekawa, T.: Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling. Cell Host & Microbe 28 (6), pp. 813 - 824.e6 (2020)
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Song, W.; Foerderer, A.; Yu, D.; Chai, J.: Structural biology of plant defence. New Phytologist (2020)
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Journal Article
Wang, J.; Chai, J.: Structural Insights into the Plant Immune Receptors PRRs and NLRs(1)([OPEN]). Plant Physiology 182 (4), pp. 1566 - 1581 (2020)
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Journal Article
Xiong, Y.; Han, Z.; Chai, J.: Resistosome and inflammasome: platforms mediating innate immunity. CURRENT OPINION IN PLANT BIOLOGY 56, pp. 47 - 55 (2020)
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2019
Journal Article
Wang, J.; Hu, M.; Wang, J.; Qi, J.; Han, Z.; Wang, G.; Qi, Y.; Wang, H.-W.; Zhou, J.-M.; Chai, J.: Reconstitution and structure of a plant NLR resistosome conferring immunity. Science 364 (6435), eaav5870, pp. 44 - + (2019)
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Journal Article
Wang, J.; Wang, J.; Hu, M.; Wu, S.; Qi, J.; Wang, G.; Han, Z.; Qi, Y.; Gao, N.; Wang, H.-W. et al.; Zhou, J.-M.; Chai, J.: Ligand-triggered allosteric ADP release primes a plant NLR complex. Science 364 (6435), eaav5868, pp. 43 - + (2019)
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Journal Article
Xiao, Y.; Stegmann, M.; Han, Z.; DeFalco, T. A.; Parys, K.; Xu, L.; Belkhadir, Y.; Zipfel, C.; Chai, J.: Mechanisms of RALF peptide perception by a heterotypic receptor complex. Nature 572 (7768), pp. 270 - + (2019)
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2011
Journal Article
Maekawa, T.; Cheng, W.; Spiridon, L. N.; Toeller, A.; Lukasik, E.; Saijo, Y.; Liu, P. Y.; Shen, Q. H.; Micluta, M. A.; Somssich, I. E. et al.; Takken, F. L. W.; Petrescu, A. J.; Chai, J.; Schulze-Lefert, P.: Coiled-Coil Domain-Dependent Homodimerization of Intracellular Barley Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death. Cell Host & Microbe 9 (3), pp. 187 - 199 (2011)
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Book Chapter (1)

2019
Book Chapter
Yang, X.; Lin, G.; Han, Z.; Chai, J.: Structural Biology of NOD-Like Receptors. In: Structural Immunology, pp. 119 - 141. SPRINGER-VERLAG SINGAPORE PTE LTD, 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE (2019)
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Preprint (2)

2025
Preprint
Lawson, A. W.; Flores-Ibarra, S.; Cao, Y.; An, C.; Neumann, U.; Gunkel, M.; Saur, I. M. L.; Chai, J.; Behrmann, E.; Schulze-Lefert, P.: The barley MLA13-AVRA13 heterodimer reveals principles for immunoreceptor recognition of RNase-like powdery mildew effectors. The EMBO Journal (2025)
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2024
Preprint
Lawson, A. W.; Macha, A.; Neumann, U.; Gunkel, M.; Chai, J.; Behrmann, E.; Schulze-Lefert, P.: A versatile protocol for purifying recombinant proteins from Nicotiana benthamiana for structural studies. bioRxiv: the preprint server for biology, 2024.10.13.618061 (2024)
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pre-print
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