Group Publications

* co-corresponding authors


Griebel T*, Lapin D*, Locci F, Kracher B, Bautor J, Concia L, Benhamed M, Parker JE*. 2023. Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity. New Phytologist. doi: 10.1111/nph.19054. abstract

Feehan JM, Wang J, Sun X, Choi J, Ahn HK, Ngou BP, Parker JE*, Jones JD*. 2023. Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation. Proc. Natl. Acad. Sci. USA 120: e2210406120, doi: 10.1073/pnas.2210406120. abstract

Johanndrees, O., Baggs, E. L., Uhlmann, C., Locci, F., Laessle, H., Melkonian, K., Käufer, K., Dongus, J. A., Nakagami, H., Krasileva, K. V.*, Parker, J. E.*, & Lapin, D*. 2023. Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1. Plant Physiology, kiac480, doi:10.1093/plphys/kiac480. abstract

Prautsch J, Erickson JL, Özyürek S, Gormanns R, Franke L, Lu Y, Marx J, Niemeyer F, Parker JE, Stuttmann J, Schattat M. H. *. 2023. Effector XopQ induced stromule formation in Nicotiana benthamiana depends on ETI signaling components ADR1 and NRG1. Plant Physiol. 191:161-176, doi: 10.1093/plphys/kiac481. abstract


Zönnchen, J. , Gantner, J., Lapin, D., Barthel, K., Eschen-Lippold, L., Erickson, J. L., Landeo Villanueva, S., Zantop, S., Kretschmer, C., Joosten, M. H. A. J., Parker, J. E., Guerois, R.,  Stuttmann, J.* 2022. EDS1 complexes are not required for PRR responses and execute TNL-ETI from the nucleus in Nicotiana benthamiana. New Phytologist, 236(6):2249-2264, doi: 10.1111/nph.18511. abstract

Platre MP, Satbhai S, Brent L, Gleason MF, Cao M, Grison M, Glavier M, Zhang L, Gaillochet C, Goeschl C, Giovannetti M, Enugutti B, Neveu J, von Reth M, Alcázar R, Parker JE, Vert G, Bayer E, Busch W*. 2022. The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants. Nat Commun. 13:4445. abstract

Huang, S., Jia, A., Song, W., Hessler, G., Meng, Y., Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Ma, S., Xiao, Y., Yu, D., Hou, J., Liu, R., Sun, H., Liu, X., Han, Z.*, Chang, J.*, Parker, J. E.*, & Chai, J.*. 2022. Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science 377, eabq3297, doi 10.1126/science.abq3297. abstract

Jia, A., Huang, S., Song, W., Wang, J., Meng, Y., Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Hou, J., Zhang, T., Yu, W., Hessler, G., Li, E., Ma, S., Yu, D., Gebauer, J., Baumann, U., Liu, X., Han, Z.*, Chang, J.*, Parker, J. E.*, & Chai, J.* 2022. TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science 377, 6605. doi: 10.1126/science.abq8180. abstract

Dongus JA, Bhandari DD, Penner E, Lapin D, Stolze SC, Harzen A, Patel M, Archer L, Dijkgraaf L, Shah J, Nakagami H, Parker JE. Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity. 2022. Plant Journal 110:1415-1432, doi: 10.1111/tpj.15747. abstract

Parker, J.*, Hessler, G., & Cui, H.* 2022. A new biochemistry connecting pathogen detection to induced defense in plants. New Phytologist. doi: 10.1111/nph.17924. abstract


Loo, E., Tajima, Y., Yamada, K., Kido, S., Hirase, T., Ariga, H., Fujiwara, T., Tanaka, K., Taji, T., Somssich, I., Parker, J. E., & Saijo, Y. 2021. Recognition of microbe/damage-associated molecular patterns by leucine-rich repeat pattern recognition receptor kinases confers salt tolerance in plants. Molecular Plant-Microbe Interactions. doi:10.1094/MPMI-07-21-0185-FI. abstract

Mahdi, L., Miyauchi, S., Uhlmann, C., Garrido-Oter, R., Langen, G., Wawra, S., Niu, Y., Guan, R., Guan, R., Robertson-Albertyn, S., Bulgarelli, D., Parker, J. E., & Zuccaro, A. 2021. The fungal root endophyte Serendipita vermifera displays inter-kingdom synergistic beneficial effects with the microbiota in Arabidopsis thaliana and barley. The ISME Journal. doi:10.1038/s41396-021-01138-y. abstract

Pruitt, R. N., Locci, F., Wanke, F., Zhang, L., Saile, S. C., Joe, A., Karelina, D., Hua, C., Fröhlich, K., Wan, W.-L., Hu, M., Rao, S., Stolze, S. C., Harzen, A., Gust, A. A., Harter, K., Joosten, M. H. A. J., Thomma, B. P. H. J., Zhou, J.-M., Dangl, J. L., Weigel, D., Nakagami, H., Oecking, C., Kasmi, F. E., Parker, J. E*., & Nürnberger, T.* 2021. The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity. Nature. doi:10.1038/s41586-021-03829-0.  abstract

Sun, X., Lapin, D., Feehan, J. M., Stolze, S. C., Kramer, K., Dongus, J. A., Rzemieniewski, J., Blanvillain-Baufumé, S., Harzen, A., Bautor, J., Derbyshire, P., Menke, F. L. H. Finkemeier, I., Nakagami, H., Jones, J. D. G.*, Parker, J. E.* 2021. Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity. Nature Communications 12: 3335, doi: 10.1038/s41467-021-23614-x. abstract

Dongus JA and Parker JE. 2021. EDS1 signalling: At the nexus of intracellular and surface receptor immunity. Curr Opin Plant Biol. 66:102039. abstract

Zhao C, Tang Y, Wang J, Zeng Y, Sun H-Q, Zheng Z, Rong S, Schneeberger K, Parker JE*, Cui H*. 2021. A mis-regulated cyclic nucleotide-gated channel mediates cytosolic calcium elevation and activates immunity in Arabidopsis. New Phytol. doi: 10.1111/nph.17218. abstract

Xing Y, Xu N, Bhandari DD, Lapin D, Sun X, Luo X, Wang Y, Cao J, Wang H, Coaker G, Parker JE, Liu J. 2021. Bacterial effector targeting of a plant iron Sensor facilitates iron acquisition and pathogen colonization. Plant Cell 33: 2015-2031, koab075, doi:10.1093/plcell/koab075. abstract

Bruessow F, Bautor J, Hoffmann G, Yildiz I, Zeier J, Parker JE (2021). Natural variation in temperature-modulated immunity uncovers transcription factor bHLH059 as a thermoresponsive regulator in Arabidopsis thaliana. 2021. PLoS Genet 17: e1009290. abstract

Chaudhry V, Runge P, Sengupta P, Doehlemann G, Parker JE, Kemen E. 2021. Shaping the leaf microbiota: plant-microbe-microbe interactions. J Exp Bot.72:36-56. doi:10.1093/jxb/eraa417. abstract


Ma, S., Lapin, D., Liu, L., Sun,Y., Song, W., Zhang, X., Logemann, E., Yu, D., Wang, J., Jirschitzka, J., Han, Z., Schulze-Lefert, P.*, Parker, J.E.*, Chai, J.* (2020) Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science 370: 6521, eabe3069. doi: 10.1126/science.abe3069. abstract

Mahdi, L., Huang, M., Zhang, X., Nakano, R. T., Kopp, L. B., Saur, I. M. L., Jacob, F., Kovacova, V., Lapin, D., Parker, J.E., Murphy, J. M., Hofmann, K., Schulze-Lefert, P., Chai, J., Maekawa, T. (2020) Innate immune signalling by plant mixed lineage kinase domain-like proteins. Cell host & microbe 28: 813-824e, doi 10.1016/j.chom.2020.08.012. abstract

Harvey, S., Kumari, P., Lapin, D., Griebel, T., Hickman, R., Guo, W., Zhang, R., Parker, J., Beynon, J., Denby, K., & Steinbrenner, J. (2020). Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility. PLoS Pathogens, 16: e1008835. doi:10.1371/journal.ppat.1008835. abstract

Lapin, D., Bhandari,D. D., Parker, J. E. (2020) Origins and Immunity Networking Functions of EDS1 Family Proteins. Annual Review of Phytopathology 58:1, 253-276, doi: 10.1146/annurev-phyto-010820-012840. abstract

Dongus, J. A., Bhandari, D. D., Patel, M., Archer, L., Dijkgraaf, L., Deslandes, L., Shah, J., & Parker, J. E. (2019). Arabidopsis PAD4 lipase-like domain is sufficient for resistance to green peach aphid. Molecular Plant-Microbe Interactions 33, 328-335, doi:10.1094/MPMI-08-19-0245-R. abstract

Neubauer, M., Serrano, I., Rodibaugh, N., Bhandari, D. D., Bautor, J., Parker, J. E., Innes, R. W. (2020) Arabidopsis EDR1 Protein Kinase Regulates the Association of EDS1 and PAD4 to Inhibit Cell Death. Molecular Plant-Microbe Interactions 33: 693-703, doi: 10.1094/MPMI-12-19-0339-R. abstract


Bailey-Serres, J., Parker, J. E., Ainsworth, E. A.Oldroyd, G. E. D., Schroeder, J.I. (2019) Genetic strategies for improving crop yields. Nature 575, 109–118, doi:10.1038/s41586-019-1679-0. abstract

Bhandari, D. D., Lapin, D., Kracher, B., von Born, P., Bautor, J., Niefind, K., & Parker, J. E. (2019). An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis. Nature Communications 10: 772. doi:10.1038/s41467-019-08783-0. abstract

Lapin, D., Kovacova, V., Sun, X., Dongus, J. A., Bhandari, D., von Born, P., Bautor, J., Guarneri, N., Rzemieniewski, J., Stuttmann, J., Beyer, A., Parker, J. E. (2019) A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors, Plant Cell 31: 2430-2455, doi: 10.1105/tpc.19.00118. abstract

Voss, M., Toelzer, C., Bhandari, D. D., Parker, J. E., Niefind, K. (2019) Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation. Journal of Structural Biology 208:107390, doi: 10.1016/j.jsb.2019.09.007. abstract


Atanasov, K. E., Liu, C., Erban, A., Kopka, J., Parker, J. E., Alcázar, R. 2018. NLR mutations suppressing immune hybrid incompatibility and their effects on disease resistance. Plant Physiology 177, 1152-1169doi: 10.1104/pp.18.00462. abstract

Cui, H., Qiu, J., Zhou, Y., Bhandari, D. D., Zhao, C., Bautor, J., Parker, J. E. 2018. Antagonism of transcription factor MYC2 by EDS1/PAD4 complexes bolsters salicylic acid defense in Arabidopsis effector-triggered immunity, Molecular Plant 11, 1053-1066, doi: 10.1016/j.molp.2018.05.007. abstract

Jacob, F., Kracher, B., Mine, A., Seyfferth, C., Blanvillain-Baufumé, S., Parker, J., Tsuda, K., Schulze-Lefert, P., Maekawa, T. 2018. A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana. New Phytologist 217, 1667-1680, doi: 10.1111/nph.14943. abstract

Joglekar, S., Suliman, M., Bartsch, M., Halder, V., Maintz, J., Bautor, J., Zeier, J., Parker, J. E.* and E. Kombrink* Chemical activation of EDS1/PAD4 signaling leading to pathogen resistance in Arabidopsis. Plant & Cell Physiology 59, 1592-1607. doi: 10.1093/pcp/pcy106. abstract


Ariga H, Katori T, Tsuchimatsu T, Hirase T, Tajima Y, Parker JE, Alcázar R, Koornneef M, Hoekenga O, Lipka AE, Gore MA, Sakakibara H, Kojima M, Kobayashi Y, Iuchi S, Kobayashi M, Shinozaki K, Sakata Y, Hayashi T, Saijo Y and Taji T. 2017. NLR locus-mediated trade-off between abiotic and biotic stress adaptation in Arabidopsis. Nature Plants 26,3:17072. doi: 10.1038/nplants.2017.72. abstract

Cui, H., Gobbato, E., Kracher, B., Qiu, J., Bautor, J., Parker, J. E., A core function of EDS1 with PAD4 is to protect the salicylic acid defense sector in Arabidopsis immunity. New Phytologist 213, 1802-1817 (2017), doi: 10.1111/nph.14302. abstract

Riedlmeier M, Ghirardo A, Wenig M, Knappe C, Koch K, Georgii E, Dey S, Parker JE, Schnitzler JP, Vlot AC. 2017. Monoterpenes support systemic acquired resistance within and between plants. Plant Cell, doi: 10.1105/tpc.16.00898. abstract


Kunz HH, Park J, Mevers E, Garcia AV, Highhouse S, Gerwick WH, Parker JE, Schroeder JI. 2016. Small molecule DFPM derivative-activated plant Resistance protein signaling in roots is unaffected by EDS1 subcellular targeting signal and chemical genetic isolation of victr R-protein mutants. PLoS One, 24;11(5):e0155937. doi: 10.1371/journal.pone.0155937. open access

Rhee SY, Mockler TC, Parker JE. 2016. A glimpse into the future of genome-enabled plant biology from the shores of Cold Spring Harbor. Genome Biol. 17:3.

Stuttmann J, Peine N, Garcia AV, Wagner C, Choudhury SR, Wang Y, James GV, Griebel T, Alcázar R, Tsuda K, Schneeberger K, Parker JE. 2016. Arabidopsis thaliana DM2h (R8) within the Landsberg RPP1-like Resistance locus underlies three different cases of EDS1-conditioned autoimmunity. PLoS Genet, 12(4), e1005990. open access


Cui H, Tsuda K, Parker JE. 2015. Effector-triggered immunity: from pathogen perception to robust defense. Annu. Rev. Plant Biol. 66, 487-511, doi: 10.1146/annurev-arplant-050213-040012.

Le Roux, C., Huet, G., Jauneau, A., Camborde, L., Tremousaygue, D., Kraut, A., Zhou, B., Levaillant, M., Adachi, H., Yoshioka, H., Raffaele, S., Berthomé, R., Couté, Y., Parker, Jane E., Deslandes, L. 2015. A Receptor Pair with an Integrated Decoy Converts Pathogen Disabling of Transcription Factors to Immunity. Cell 161, 5, 1074-1088.

Makandar R, Nalam VJ, Chowdhury Z, Sarowar S, Klossner G, Lee H, Burdan D, Trick HN, Gobbato E, Parker JE and Shah J 2015. The combined action of ENHANCED DISEASE SUSCEPTIBILITY1, PHYTOALEXIN DEFICIENT4 and SENESCENCE-ASSOCIATED GENE101 promotes salicylic acid-mediated defences to limit Fusarium graminearum infection in Arabidopsis thaliana. Mol. Plant-Microbe Interact. 28, 943-953.


Alcázar, R., von Reth, M., Bautor, J., Chae, E., Weigel, D., Koornneef, M. and Parker, J.E. 2014. Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility and its occurrence in nature. PloS Genetics, 10(12): e1004848.DOI: 10.1371/journal.pgen.1004848 (2014).

Breitenbach HH, Wenig M, Wittek F, Jorda L, Maldonado-Alconada AM, Sarioglu H, Colby T, Knappe C, Bichlmeier M, Pabst E, Mackey D, Parker JE, Vlot AC. 2014. Contrasting roles of apoplastic aspartyl protease AED1 and legume lectin-like protein LLP1 in Arabidopsis systemic acquired resistance. Plant Physiol. 165, 791-809.

Carstens M, McCrindle TK, Adams N, Diener A, Guzha DT, Murray SL, Parker, JE, Denby KJ and Ingle RA. 2014. Increased resistance to biotrophic pathogens in the Arabidopsis Constitutive Induced Resistance 1 mutant is EDS1 and PAD4-dependent and modulated by environmental temperature. PLoS One 9, e0109853.

Doehlemann G, Requena N, Schaefer P, Brunner F, O’Connell R, Parker JE. 2014. Reprogramming of plant cells by filamentous plant-colonizing microbes. New Phytol. 204, 803-814.

Gloggnitzer,J., Akimcheva,S., Srinivasan, A., Kusenda, B., Riehs, N., Stampfl,H.J., Bautor,J., Dekrout,B., Jonak, C., Jiménez-Gómez,J. M., Parker, J. E., Riha, K. 2014. Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense. Cell Host & Microbe, 16, 376-390. doi:10.1016/j.chom.2014.08.010.

Griebel T, Maekawa T and Parker JE. 2014. Nucleotide-binding oligomerization domain-like receptor cooperativity in effector-triggered immunity. Trends Immunol. 35, 562-570.

Parker JE. 2014. Co-opting the cell-cycle machinery for plant immunity. Cell Host Microbe 16, 707-709.

Pel MJC, Wintermans PCA, Cabral A, Robrock BJM, Seidl MF, Bautor J, Parker JE, van den Ackerveken G, Pieterse CMJ. 2014. Functional analysis of Hyaloperonospora arabidopsidis RxLR effectors. PLoS One 9, e110624. abstract

Williams, S.J., Hoon Sohn, K., Wan, L., Bernoux, M., Sarris, P. F., Segonzac, C., Ve, T., Ma, Y., Saucet, S. B., Ericsson, D. J., Casey, L. W., Lonhienne, T., Winzor, D. J., Zhang, X., Coerdt, A., Parker, J. E., Dodds, P. N., Kobe, B. and Jonathan D. G. Jones. 2014. Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor. Science 344 (6181), 299-303. DOI:10.1126/science.1247357.

Wittek F, Hoffmann T, Kanawati B, Bichlmeier M, Knappe C, Wenig M, Schmitt-Kopplin P, Parker JE, Schwab W and Vlot AC. 2014. Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 promotes systemic acquired resistance via azelaic acid and its precursor 9-oxo nonanoic acid. J. Exp. Bot. 65, 5919-5931.


Heidrich, K., Tsuda, K., Blanvillain-Baufumé, S., Wirthmueller, L., Bautor, J. and Parker, J.E. 2013. Arabidopsis TNL-WRKY domain receptor RRS1 contributes to temperature conditioned RPS4 auto-immunity. Frontiers Plant Sci. 4: Article 403 pdf.

Hoser, R., Żurzak, M., Lichocka, M., Zuzga, S., Dadlez, M., Samuel, M.A., Ellis, B.E., Stuttmann, J., Parker, J.E., Hennig, J. and Krzymowska, M. 2013. Nucleocytoplasmic partitioning of tobacco N receptor is modulated by SGT1. New Phytol. 200: 158-171. abstract

Wagner, S., Stuttmann, J., Rietz, S., Guerois, R., Brunstein, E., Bautor, J., Niefind, K. and Parker, J.E. 2013. Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity. Cell Host Microbe, 14:619-630. abstract

Zbierzak, A.M., Porfirova, S., Griebel, T., Melzer, M., *Parker, J.E. and *Dörmann, P. 2013. A TIR-NBS protein encoded by Arabidopsis Chilling Sensitive 1 ( CHS1) limits chloroplast damage and cell death at low temperature. Plant Journal 75:539-552. *Corresponding authors. abstract


Kim, T.-H., Kunz, H.-H., Bhattacharjee, S., Hauser, F., Park, J., Engineer, C., Liu, A., Ha, T., Parker J. E., Gassmann, W., Schroeder, J. I. 2012. Natural Variation in Small Molecule–Induced TIR-NB-LRR Signaling Induces Root Growth Arrest via EDS1- and PAD4-Complexed R Protein VICTR in Arabidopsis. Plant Cell 25, 5177-5192. abstract

Shin, J., Heidrich, K., Sanchez-Villarreal, A., Parker, J.E. and Davis, S.J. 2012. TIME FOR COFFEE represses MYC2 protein accumulation to provide time-of-day regulation of jasmonate signaling. Plant Cell 24: 2470-2482. pdf

Heidrich, K., Blanvillain-Baufumé, S. and Parker, J.E. 2012. Molecular and spatial constraints on NB-LRR receptor signaling. Curr. Opin. Plant Biol. 15: 385-391. abstract

Louis, J., Gobbato, E., Mondal, H.A., Feys, B.J., Parker, J.E. and Shah, J. 2012. Discrimination of Arabidopsis PAD4 activities in defense against green peach aphid and pathogens. Plant Physiol. 158: 1860-1872. pdf


Heidrich, K., Wirthmueller, L., Tasset, C., Pouzet, C., Deslandes, L and Parker, J.E. 2011. Arabidopsis EDS1 connects pathogen effector recognition to cell compartment-specific immune responses. Science 334: 1401-1404.

Alcázar, R. and Parker, J.E. 2011. The impact of temperature on balancing immune responsiveness and growth in Arabidopsis. Trends Plant Sci. 16, doi:10.1016/j.tplants.2011.09.001. abstract

Fabro, G., Steinbrenner, J., Coates, M., Ishaque, N., Baxter, L., Studholme, D.J., Körner, E., Allen, R.L., Piquerez, S.J.M., Rougon-Cardoso, A., Greenshields, D., Lei, R., Badel, J.L., Caillaud, M.-C., van den Ackerveken, G., Parker, J.E., Beynon, J. and Jones, J.D.G. 2011. The effectorome from the obligate biotroph Hyaloperonospora arabidopsidis reveals redundant roles in suppression of PAMP-triggered immune response. PLoS Pathogens, 7: e1002348. pdf

Stuttmann, J., Hubberten, H.-M., Rietz, S., Kaur, J., Muskett, P, Guerois, R., Bednarek, P., Hoefgen, R. and Parker, J.E. 2011. Perturbation of Arabidopsis amino acid metabolism casues incompatibility with the adapted biotrophic pathogen Hyaloperonospora arabidopsidis. Plant Cell 23: 2788-2803. pdf

Cabral, A. Stassen, J.H.M., Seidl, M.F., Bautor, J., Parker, J.E. and van den Ackerveken, G. 2011. Identification of Hyaloperonospora arabidopsidis transcript sequences expressed during infection reveals isolate-specific effectors. PLoS One, 6: e19328. pdf

Winter, C.M., Austin, R.S., Blanvillain-Baufumé, S., Reback, M.A., Monniaux, M.,Wu, M.-F., Sang, Y., Yamaguchi, A., Yamaguchi, N., Parker, J.E., Parcy, F., Jensen, S.T., Li, H. and Wagner, D. 2011. LEAFY target genes reveal floral regulatory logic, cis motifs and a link to biotic stimulus response. Dev. Cell 20: 430-443. abstract

Kim, T.-H., Hauser, F., Ha, T., Xue, S., Böhmer, M., Nishimura, N., Munemasa, S., Hubbard, K., Peine, N., Lee, B., Lee, S., Robert, N., Parker, J.E. and Schröder, J.I. 2011. Chemical genetics reveals negative regulation of abscisic acid signaling by a plant immune response pathway. Curr Biol. 21:990-997. abstract

Lenz, H.D., Haller, E., Melzer, E., Kober, K., Wurster, K., Stahl, M., Bassham, D.C., Vierstra, R.D., Parker, J.E., Bautor, J., Molina, A., Escudero, V., Shindo, T., van der Hoorn, R.A.L., Gust, A.A. and Nürnberger, T. 2011. Autophagy differentially controls plant basal immunity to biotrophic and necrotrophic pathogens. Plant J. 66:818-830. abstract

Rietz, S., Stamm, A., Malonek, S., Wagner, S., Becker, D., Medina-Escobar, N., Vlot, A.C., Feys, B.J., Niefind, K., and Parker, J.E. 2011. Different roles of EDS1 bound to and dissociated from PAD4 in Arabidopsis immunity. New Phytol. 191:107-119. abstract

Uppalapati, S.R, Ishiga, Y., Ryu, C.-M., Ishiga, T., Wang, K., Noël, L.D., Parker, J.E. and Mysore, K.S. 2011. SGT1 contributes to coronatine signaling and Pseudomonas syringae pv. tomato disease symptom development in tomato and Arabidopsis. New Phytol. 189: 83-93. abstract

Wagner, S., Rietz, S., Parker, J.E., and Niefind, K. 2011. Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant defense, in complex with its signaling partner SAG101. Acta Crystallogr. F 67: 245-248. abstract


Alcázar, R., García, A.V., Kronholm, I., de Meaux, J., Koornneef, M., Parker, J.E. and Reymond, M. 2010. Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between A. thaliana accessions. Nature Genetics 42:1135-1139. abstract

Parker, J.E. and Ellis, J.G. (Eds). 2010. Plant-biotic interactions: advances on all fronts. Curr. Opin. Plant Biol. 13:363-365. abstract

Wiermer, M., Germain, H., Cheng, Y., Garcia, A.V., Parker, J.E. and Li, X. 2010. Nucleoporin MOS7/Nup88 contributes to plant immunity and nuclear accumulation of defense regulators. Nucleus 1: 1-5.  abstract

Bartsch, M., Bednarek, P., Vivancos, P.D., Schneider, B., von Roepenack-Lahaye, E., Foyer, C.H., Kombrink, E., Scheel, D. and Parker, J.E. 2010. Accumulation of isochorismate-derived 2,3-dihidroxybenzoic 3-O-β-D-xyloside in Arabidopsis resistance to pathogens and ageing of leaves. J. Biol. Chem. 285: 25654-25665. abstract

Rietz, S., Dermendjiev, G., Oppermann, E., Tafesse, F.G., Effendi, Y., Holk, A., Parker, J.E., Teige, M. and Scherer, G.F. 2010. Roles of Arabidopsis patatin-related phospholipases A in root development are related to auxin responses and phosphate deficiency. Mol. Plant 3:524-538. abstract

Garcia, A.V., Blanvillain-Baufumé, S., Huibers, R.P., Wiermer, M, Li, G., Gobbato, E., Rietz, S. and Parker, J.E.2010. Balanced nuclear and cytoplasmic activities of EDS1 are required for a complete plant innate immune response. PLoS Pathogens 6: e1000970. pdf

Straus, M.R., Rietz, S., Ver Loren van Themaat, E., Bartsch, M. and Parker, J.E. 2010. Salicylic acid antagonism of EDS1-driven cell death is important for Arabidopsis immune and oxidative stress responses. Plant Journal 62: 628-640. abstract


Stuttmann, J., Parker, J.E. and Noël, L.D. 2009. Novel aspects of COP9 signalosome functions revealed through analysis of hypomorphic csn mutants. Plant Signaling and Behaviour 4(9):896 - 898. pdf

Cheng, Y.T, Wiermer, M., Germain, H., Bi, D., Xu, F., Garcia, A.V., Wirthmüller, L., Depres, C., Parker, J.E., Zhang, Y. and Li, X. 2009. Nuclear pore complex component MOS7/Nup88 is required for plant innate immunity and nuclear accumulation of defense regulators in Arabidopsis. Plant Cell 21:2503-2516. pdf

Birker, D., Heidrich, K., Takahara, H., Narusaka, M., Deslandes, L., Narusaka, Y., Reymond, M., Parker, J.E. and O’Connell, R. 2009. A locus conferring resistance to Colletotrichum higginsianum is shared by four geographically distinct Arabidopsis accessions. Plant Journal 60: 602-613. pdf

Garcia, A.V. and Parker, J.E. 2009. Heaven’s Gate: Nuclear accessibility and activities of plant immune regulators. Trends in Plant Sci. 14: 479-787. pdf

Chang CC, Slesak I, Jordá L, Sotnikov A, Melzer M, Miszalski Z, Mullineaux PM, Parker JE, Karpinska B, Karpinski S. 2009: Arabidopsis chloroplastic glutathione peroxidases play a role in cross talk between photooxidative stress and immune responses. Plant Physiol. 150: 670-83. pdf

Panstruga, R., Parker, J. and Schulze Lefert, P. 2009. SnapShot: Plant Immune Response Pathways. Cell 136:978.e1

Stuttmann, J., Lechner, E., Guérois, R., Parker, J.E., Nussaume, L., Genschick, P., Noël, L.D. 2009. COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis. J. Biol. Chem. 284: 7920-7930. pdf

Alcázar, R., Garcia, A.V., Parker, J.E. and Reymond, M. 2009. Incremental steps towards incompatibility revealed by Arabidopsis epistatic interactions modulating salicylic pathway activation. Proc. Natl. Acad. Sci. USA 106: 334-339. pdf


Parker, J.E. (Ed). 2008. Molecular Aspects of Plant Disease Resistance. Wiley-Blackwell Annu. Plant Rev. Vol. 34.

Mühlenbock, P., Szechyńska-Hebda, M., Płaszczyca, M., Baudo, M., Mullineaux. P.M., Parker, J.E., Karpińska, B. and Karpiński, S. 2008. Chloroplast signaling and LESION SIMULATING DISEASE 1 regulate crosstalk between light acclimation and immunity in Arabidopsis. In: Plant Cell, 20, 2339-2356. pdf

Llorente, F., Muskett, P., Sánchez-Vallet, A., López, G., Sánchez-Rodriguez, C., Ramos, B., Jordá, L., Parker, J. and Molina, A. 2008. Repression of the auxin response pathway increases Arabidopsis susceptibility to necrotrophic fungi. Mol. Plant 1: 496-509. pdf

Stuttmann, J., Parker, J.E. and Noël, L.D. 2008. Staying in the fold: The SGT1/chaperone machinery in maintenance and evolution of leucine-rich-repeat proteins. Plant Signaling & Behavior 3: 283-285. pdf

Kwon, C., Neu, C., Pajonk, S., Yun, H.-S., Lipka, U., Humphry, M.E., Bau, S., Straus, M., Rampelt, H., El Kasmi, F., Jürgens, G., Parker, J., Panstruga, R., Lipka, V. and Schulze-Lefert, P. 2008. Co-option of a default secretory pathway for plant immune responses, Nature 451: 835-840. pdf

Zhou, F., Mosher, S., Tian, M., Sassi, G., Parker, J., Klessig, D.F. 2008. The Arabidopsis gain-of-function mutant ssi4 requires RAR1 and SGT1b differentially for defence activation and morphological alterations. Mol. Plant-Microbe Interactions 21: 40-49. pdf


Noël, L.D., Cagna, G., Stuttmann, J., Wirthmüller, L., Betsuyaku, S., Witte, C.-P., Bhat, R., Pochon, N., Colby, T. and Parker, J.E. 2007. Interaction between SGT1 and cytosolic HSC70 chaperones regulates Arabidopsis immune responses. Plant Cell 19: 4061-4076. pdf

Wirthmüller, L., Zhang, Y., Jones, J.D.G. and Parker, J.E. 2007. Nuclear accumulation of the Arabidopsis immune receptor RPS4 is necessary for triggering EDS1-dependent defence. Curr. Biol. 17: 2023-2029. pdf

Pegadaraju, V., Louis, J., Singh, V., Reese, J.C., Bautor, J., Feys, B.J., Cook, G., Parker, J.E. and Shah, J. 2007. Phloem-based resistance to green peach aphid is controlled by Arabidopsis PHYTOALEXIN DEFICIENT4 without its signaling partner ENHANCED DISEASE SUSCEPTIBILITY1. Plant Journal 52, 332-34. pdf

Rietz, S. and Parker, J.E. 2007. Plant disease and defence. Encyclopedia of Life Sciences. J. Wiley & Sons. [DOI:10.1002/9780470015902.a0004036].

Kemmerling, B., Schwedt, A., Rodriguez, P., Mazzotta, S., Frank, M., Qamar, S.A., Mengiste, T., Betsuyaku, S., Parker, J.E., Müssig, C., Thomma, B.P.H.J., Albrecht, C., de Vries, S.C., Hirt, H. and Nürnberger, T. 2007. A brassinolide-independent role for the BRI1 associated receptor kinase (BAK1) in plant cell death control. Curr. Biol. 17: 1116-1122. pdf


Brodersen, P., Petersen, M., Nielsen, H.B., Zhu, S., Newman, M.A., Shokat, K.M., Rietz, S., Parker, J. and Mundy, J. 2006. Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. Plant J. 47: 532-546. pdf

Azevedo, C., Betsuyaku, S., Peart, J., Takahashi, A., Noël, L., Sadanandom, A., Casais, C., Parker, J. and Shirasu, K. 2006. Role of SGT1 in Resistance protein accumulation in plant immunity. EMBO J. 25: 2007-2016. pdf

Bartsch, M., Gobbato, E., Bednarek, P., Debey, S., Schultze, J.L., Bautor, J. Parker, J.E. 2006. Salicylic acid-independent EDS1 signaling in Arabidopsis immunity and cell death is regulated by the monooygenase FMO1 and the Nudix hydrolase NUDT7. Plant Cell 18: 1038-1051. pdf


Lipka, V., Dittgen, J., Bednarek, P., Bhat, R., Wiermer, M., Stein, M., Landtag, J., Brandt, W., Rosahl, S., Scheel, D., Llorente, F., Molina, A., Parker, J., Sommerville, S. and Schulze-Lefert, P. 2005. Pre- and post-invasion defences both contribute to non-host resistance in Arabidopsis. Science 310: 1180-1183. pdf

Wiermer, M., Feys, B.J. and Parker, J.E. 2005. Plant immunity: the EDS1 regulatory node. Curr. Opin. Plant Biol. 8: 383-389. pdf

Feys, B.J., Wiermer, M., Bhat, R.A., Moisan, L.J., Medina-Escobar, N., Neu, C., Cabral A. and Parker J.E. 2005. Arabidopsis SENESCENCE ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity. Plant Cell 17: 2601-2613. pdf

Pajerowska, K.M., Parker, J.E. and Gebhardt, C. 2005. Potato homologues of Arabidopsis thaliana genes functional in defence signaling – Identification, genetic mapping and molecular cloning. Mol. Plant-Microbe Interact. 18, 1107-1119. pdf

S. Xiao, O. Calis, E. Patrick, G. Zhang, P. Charoenwattana, P. Muskett, J. E. Parker & J.G. Turner. 2005. The atypical Resistance gene, RPW8, recruits components of basal defence for powdery mildew resistance in Arabidopsis. Plant J. 42, 95-110. pdf


A. Mateo, P. MŸhlenbock, C. Rustérucci, C.C. Chen, Z. Miszalski, B. Karpinska, J.E. Parker, P.M. Mullineaux and S. Karpinski. 2004. Lesion Simulating Disease 1 is required for acclimation to conditions that promote excess light energy. Plant Physiol. 136, 2818-2830.

C.P. Witte, L.D. Noel, J. Gielbert, J.E. Parker and T. Romeis. 2004. Rapid one-step protein purification from plant material using the eight amino acid StrepII tag. Plant Mol. Biol. 55, 135-147. pdf


Parker, J.E. 2003. Plant Immunity: a complex interface between host and pathogen. Transgenic Research 11: 565-566. pdf

Baker, B. and Parker, J. 2003. Signals from the environment: the good, the bad and the ugly! Curr. Opin. Plant Biol. 6: 297-299.

Muskett, P.M. and Parker, J. 2003. Role of SGT1 in the regulation of plant R gene signalling. Microbes and Infection 5: 969-976. pdf

W.M. Gray, P.R. Muskett, H.-W. Chuang and J.E. Parker. 2003. Arabidopsis SGT1b is required for SCFTIR1-mediated auxin response. Plant Cell 15, 1310-1319. pdf

Hammond-Kosack, K.E and Parker, J.E. 2003. Deciphering plant-pathogen communication: fresh perspectives for molecular resistance breeding. Curr. Opin. Biotechnol. 14: 177-193. pdf


A. Varet, J.E. Parker, P. Tornero, N. Nass, T. Nuernberger, J.L. Dangl, D. Scheel and J. Lee. 2002. NHL25 and NHL3, two NDR1/HIN1-like genes in Arabidopsis thaliana with potential role(s) in plant defence. Mol. Plant-Microbe Interact., 15, 608-616.

P.M. Muskett, K. Kahn, M.J. Austin, L.J. Moisan, A. Sadanandom, K. Shirasu, J.D.G. Jones and J.E. Parker. 2002. Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defences against multiple pathogens. Plant Cell, 14, 979-992.

M.J. Austin, P. R. Muskett, K. Kahn, B.J. Feys, J.D.G. Jones and J.E. Parker. 2002. Regulatory role of SGT1 in early R gene-mediated plant defences. Science 295, 2077-2080. pdf

J.R. Peart, G. Cook, B.J. Feys, J.E. Parker and D.C. Baulcombe. 2002. An EDS1 orthologue is required for N-mediated resistance against tobacco mosaic virus. Plant J. 29, 569-579. pdf

E.A. van der Biezen, C.T. Freddie, K. Kahn, J.E. Parker and J.D.G. Jones. 2002. Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signaling components. Plant J. 29, 439-451. pdf

D.H. Aviv, C. Rustérucci, Ben F. Holt III, R.A. Dietrich, J.E. Parker and J.L. Dangl. 2002. Runaway cell death but not basal disease resistance, in lsd1 is SA- and NIM1/NPR1-dependent. Plant J. 29, 381-391. pdf


B.J. Feys, L.J. Moisan, M.A. Newman and J.E. Parker. 2001. Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4. EMBO J. 20, 5400-5411. pdf

J.E. Parker, N. Aarts, M.A. Austin, B.J. Feys, L.J. Moisan, P. Muskett and C. Rustérucci,. 2001. Genetic analysis of plant disease resistance pathways. In Rice Biotechnology: improving yield, stress tolerance and grain quality. Wiley, Chichester (Novartis Foundation Symposium 236) pp.153-164.

C. Rustérucci, D.H. Aviv, B.Holt III, J.L. Dangl and J.E. Parker. 2001. The disease resistance signaling components EDS1 and PAD4 are essential regulators of the cell death pathways controlled by LSD1 in Arabidopsis. Plant Cell, 13, 2211-2224. pdf

J.D. Clarke, N. Aarts, B.J. Feys, X. Dong and J.E. Parker. 2001. Constitutive disease resistance requires EDS1 in the Arabidopsis mutants cpr1 and cpr6 and is partially EDS1-dependent in cpr5. Plant J. 26, 409-420.


B.J. Feys and J.E. Parker. 2000. Interplay of signalling pathways in plant disease resistance. Trends in Genetics 16, 449-455. pdf

J.E. Parker. 2000. Signalling in Plant Disease Resistance. In Annual Plant Reviews. Vol.4, Eds: J.L. Beynon and M. Dickinson. Academic Press, Sheffield pp.144 - 174.

J.E. Parker, B.J. Feys, E.A. van der Biezen, L. Noël, N.Aarts, M.J. Austin, M.A. Botella, L.N. Frost, M.J. Daniels and J.D.J. Jones. 2000. Unraveling R gene-mediated disease resistance pathways in Arabidopsis. Mol. Plant Pathol. 1, 17-24.

M. Petersen, P. Brodersen, H. Naested, E. Andreasson, U. Lindhart, B. Johansen, H.B. Nielsen, M. Lacy, M.J. Austin, J.E. Parker, S.B. Sharma, D.F. Klessig, R. Martienssen, O. Mattsson, A.B. Jensen and J. Mundy. 2000. Arabidopsis MAP Kinase 4 negatively regulates systemic acquired resistance. Cell 103, 1111-1120.

E.A. van der Biezen, H. Juwana, J.E. Parker and J.D.G. Jones. 2000. cDNA-AFLP display for the isolation of Peronospora parasitica genes expressed during infection in Arabidopsis thaliana. Mol. Plant-Microbe Interact. 13, 895-898.


D. Jirage, T.L. Tootle, T.L. Reuber, L.N. Frost, B.J. Feys, J.E. Parker, F.M. Ausubel and J. Glazebrook. 1999. Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signalling. Proc. Natl. Acad. Sci. USA 96, 13583-13588. pdf

L. Noël, T.L. Moores, Erik.A. van der Biezen, M. Parniske, M.J. Daniels, J.E. Parker, J.D.G. Jones. 1999. Pronounced intraspecific haplotype divergence at the RPP5 complex disease resistance locus of Arabidopsis. Plant Cell 11, 1-14.

Falk, B.J. Feys, L.N. Frost, J.D.G. Jones, M.J. Daniels and J.E. Parker1. 1999. EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Proc. Natl. Acad. Sci. USA 96, 3292-3297. pdf


I.-C. Yu, J.E. Parker and A.F. Bent. 1998. Gene-for-gene resistance without the hypersensitive response in Arabidopsis dnd1 mutant. Proc. Natl. Acad. Sci. USA 95, 7819-7824.

N. Aarts, M. Metz, E. Holub, B.J. Staskawicz, M.J. Daniels and J.E. Parker1. 1998. Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis. Proc. Natl. Acad. Sci. USA 95, 10306-10311. pdf

M. Botella, J.E. Parker, L.N. Frost, P.D. Bittner-Eddy, J.L. Beynon, M.J. Daniels, E. B. Holub and J.D.G. Jones. 1998. Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasitica avirulence determinants. Plant Cell 10, 1847-1860.


J.E. Parker, M.J. Coleman, V. Szabò, L.N. Frost, R. Schmidt, E.A. van der Biezen, T. Moores, C. Dean, M.J. Daniels and J.D.G. Jones. 1997. The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the Toll and Interleukin-1 receptors with N and L6. Plant Cell 9, 879-894.

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