MorphoGraphX has been used in various groups to investigate growth, mechanics, gene expression and protein localization in both plant and animal systems. Below is a list of published work using MorphoGraphX.

If you use MorphoGraphX in your research, please refer to this paper (eLife 2015;4:e05864) and let us know about your publications.


Barbier de Reuille, P., Routier-Kierzkowska, A.-L., Kierzkowski, D., Bassel, G.W., Schüpbach, T., Tauriello, G., Bajpai, N., Strauss, S., Weber, A., Kiss, A., Burian, A., Hofhuis, H., Sapala, A., Lipowczan, M., Heimlicher M.B., Robinson, S., Bayer, E.M., Basler, K., Koumoutsakos, P., Roeder, A.H.K., Aegerter-Wilmsen, T., Nakayama, N., Tsiantis, M., Hay, A., Kwiatkowska, D., Xenarios, I., Kuhlemeier, C. & Smith, R.S. (2015) MorphoGraphX: A platform for quantifying morphogenesis in 4D. eLife 4:e05864

Montenegro-Johnson, T. D., Stamm, P., Strauss, S., Topham, A. T., Tsagris, M., Wood, A. T., Smith, R.S. & Bassel, G. W. (2015). Digital Single-Cell Analysis of Plant Organ Development Using 3DCellAtlas. The Plant Cell 27(4), 1018-1033.

Shapiro, B. E., Tobin, C., Mjolsness, E., & Meyerowitz, E. M. (2015). Analysis of cell division patterns in the Arabidopsis shoot apical meristem. PNAS, 112(15), 4815-4820.

  De Rybel, B., Adibi, M., Breda, A. S., Wendrich, J. R., Smit, M. E., Novák, O., Yamaguchi, N., Yoshida, S., Van Isterdael, G., Palovaara, J., Nijsse, B.,Boekschoten, M.V.,Hooiveld, G., Beeckman, T., Wagner, D., Ljung, K., Fleck, C.  & Weijers, D. (2014). Integration of growth and patterning during vascular tissue formation in Arabidopsis. Science, 345(6197), 1255215.
Bassel, G. W., Stamm, P., Mosca, G., Barbier de Reuille, P., Gibbs, D. J., Winter, R., Janka, Holdsworth, M. J. & Smith, R. S. (2014). Mechanical constraints imposed by 3D cellular geometry and arrangement modulate growth patterns in the Arabidopsis embryo. PNAS, 201404616.
Yoshida, S., Barbier de Reuille, P., Lane, B., Bassel, G. W., Prusinkiewicz, P., Smith, R. S., & Weijers, D. (2014). Genetic Control of Plant Development by Overriding a Geometric Division Rule. Developmental cell, 29(1), 75-87.
Sampathkumar, A., Krupinski, P., Wightman, R., Milani, P., Berquand, A., Boudaoud, A., Hamant, O., Jonsonn, E., & Meyerowitz, E. M. (2014). Subcellular and supracellular mechanical stress prescribes cytoskeleton behavior in Arabidopsis cotyledon pavement cells. ELife, 3.
Vlad, D., Kierzkowski, D., Rast, M. I., Vuolo, F., Ioio, R. D., Galinha, C., Gan X., Hajheidari M., Hay A., Smith R. S., Huijser P., Bailey C. D., & Tsiantis, M. (2014). Leaf Shape Evolution Through Duplication, Regulatory Diversification, and Loss of a Homeobox Gene. Science, 343(6172), 780-783.
Barbier de Reuille, P., Robinson, S., & Smith, R. S. (2014). Quantifying Cell Shape and Gene Expression in the Shoot Apical Meristem Using MorphoGraphX. In Plant Cell Morphogenesis (pp. 121-134). Humana Press.

Bert De Rybel B; Möller B; Yoshida S; Grabowicz I; Barbier de Reuille P; Boeren S, Smith RS; Borst JW; Weijers D (2013). A bHLH Complex Controls Embryonic Vascular Tissue Establishment and Indeterminate Growth in Arabidopsis. Developmental Cell. 24(4): 426-437.
Kierzkowski, D., Lenhard, M., Smith, R., & Kuhlemeier, C. (2013). Interaction between meristem tissue layers controls phyllotaxis. Developmental cell, 26(6), 616-628.
Wabnik, K., Robert, H. S., Smith, R. S., & Friml, J. (2013). Modeling framework for the establishment of the apical-basal embryonic axis in plants. Current Biology, 23(24), 2513-2518.
Nakayama, N., Smith, R. S., Mandel, T., Robinson, S., Kimura, S., Boudaoud, A., & Kuhlemeier, C. (2012). Mechanical regulation of auxin-mediated growth. Current Biology, 22(16), 1468-1476.
Kierzkowski, D., Nakayama, N., Routier-Kierzkowska, A. L., Weber, A., Bayer, E., Schorderet, M., Reinhardt, D., Kuhlemeier, C. & Smith, R. S. (2012). Elastic domains regulate growth and organogenesis in the plant shoot apical meristem. Science, 335(6072), 1096-1099.
Aegerter-Wilmsen, T., Heimlicher, M. B., Smith, A. C., de Reuille, P. B., Smith, R. S., Aegerter, C. M., & Basler, K. (2012). Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development, 139(17), 3221-3231.
Chitwood, D. H., Headland, L. R., Ranjan, A., Martinez, C. C., Braybrook, S. A., Koenig, D. P., Kuhlemeier, C., Smith, R. S. & Sinha, N. R. (2012). Leaf asymmetry as a developmental constraint imposed by auxin-dependent phyllotactic patterning. The Plant Cell Online, 24(6), 2318-2327.

Santuari, L., Scacchi, E., Rodriguez-Villalon, A., Salinas, P., Dohmann, E., Brunoud, G., Vernoux, T., Smith, R.S. & Hardtke, C. S. (2011). Positional Information by Differential Endocytosis Splits Auxin Response to Drive Arabidopsis Root Meristem Growth. Current Biology, 21(22), 1918-1923.
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